Can you move programs and folders from 1 drive to another without having a problem on your computer?

My 5-yr-old computer is very slow, even though I run the cleanup programs often. After working on it for a few hours, I sometimes get the message that there is not enough memory to do something, like Save, Copy and Paste, etc.

I am setting up an ecommerce business on my computer, so I need as much space/memory as I can get. It is a custom-built computer with Genuine Intel x86 and 384 MG RAM. I have 3 drives, C has 57.19 GB, D has 1.16 GB (was moved from C by repair person because it was comtaminated and quarantined, and my computer considers this move an error). My E drive has 65.77 GB (and I don't know what is on it, as I haven't looked), for a total of 124.09 GB. I want to know if my computer would have a problem with my moving my Program Applications or some other Folders from C to E?

Also, If I get a new computer, can I move the C and E drives to add GBs to that one and avoid having to copy their contents? Or would that transfer viruses to the new one? Thanks for your help.

Can you move programs and folders from 1 drive to another without having a problem on your computer?microsoft office

I want to know if my computer would have a problem with my moving my Program Applications or some other Folders from C to E?

: there is no problem moving your program applications form C to E, but first when you move program application to E make sure that the program is not running. second be sure that the programs and files dont have virus. so before you copy them run your anti-virus software first.